Cardiac adenosine 3':5'-monophosphate. Free and bound forms in the isolated rat atrium.

Cyclic Adenosine Monophosphate and Cardiac

• This review examines critically the evidence bearing on the hypothesis that the positive inotropic effects of catecholamines are mediated by intracellular cyclic adenosine monophosphate (cyclic AMP). The review is selective in several respects. For example, it does not contain extensive discussions about the biochemical actions of cyclic AMP, the enzymes regulating its synthesis and degradati...

Cyclic adenosine monophosphate and cardiac contractility.

• This review examines critically the evidence bearing on the hypothesis that the positive inotropic effects of catecholamines are mediated by intracellular cyclic adenosine monophosphate (cyclic AMP). The review is selective in several respects. For example, it does not contain extensive discussions about the biochemical actions of cyclic AMP, the enzymes regulating its synthesis and degradati...

The relation between reduced protein degradation and elevated adenosine 3',5'-monophosphate in isolated rat atria.

We studied the effect on protein degradation of agents that alter intracellular adenosine 3',5'-monophophate (cyclic AMP) in isolated rat right atria. Protein degradation rate was determined by measurement of the rate of release of L-tyroslne from atria cultured in the presence of cycloheximide. Stimulation of adenylate cyclase activity by either L-isoproterenol, glucagon, prostaglandin Ei, pro...

Adenosine-guanosine interactions in the isolated dog atrium.

Metabolism and excretion of exogenous adenosine 3':5'-monophosphate and guanosine 3':5'-monophosphate. Studies in the isolated perfused rat kidney and in the intact rat.

Isolated rat kidneys were perfused with a recirculating medium containing exogenous adenosine 3':5'-monophosphate (cyclic AMP) or guanosine 3':5'-monophosphate (cyclic GMP) at an initial concentration of 0.1 mM. Both cyclic nucleotides were rapidly removed from the perfusate. Urinary excretion accounted for about 20% and 40% of the respective cyclic AMP and cyclic GMP lost from the perfusate. T...